Can you Take Benadryl and Melatonin

Take Benadryl and Melatonin

Benadryl is one of the most common over-the-counter medications used for treating symptoms of hay fever and allergies (and sometimes also the common cold) like watery and itchy eyes, itchy nose and ears, runny nose, sneezing, and rashes. Bamboo sheets moisture wicking and hypoallergenic properties can also assist with allergies. To know about Take Benadryl and Melatonin must read this article.

If taken regularly , It may be habit-forming, meaning a psychological dependency may occur, rather than a physical dependenc .  

You can get this medication in the following dosage forms:

  • Diphenhydramine hydrochloride tablet
  • Diphenhydramine hydrochloride capsule
  • Diphenhydramine hydrochloride liquid-filled capsule
  • Diphenhydramine hydrochloride solution

Benadryl interactions with supplements

It’s possible for drugs to interact with supplements such as vitamins and herbs.

Benadryl interactions with herbs

There were no specific reports of herbs interacting with Benadryl. However, it’s still important to check with your doctor or pharmacist before taking any of these products during Benadryl treatment.

Benadryl interactions with vitamins

Vitamins have not been reported to interact with Benadryl. You should still talk with keep your mind your doctor or pharmacist before taking any vitamins during your Benadryl treatment.

Benadryl interactions with food

No food interactions with Benadryl have been reported. If you’d like to learn more about eating certain foods while you take Benadryl, talk with your doctor.

Benadryl interactions with vaccines

There were no reports of vaccines interacting with Benadryl. Your doctor can tell you more about vaccines and Benadryl.

Benadryl interactions with lab tests

Lab tests have not been reported to interact with Benadryl. If you’d like additional information about having lab tests while taking Benadryl, talk with your doctor.


Melatonin is a hormone produced by the pineal gland in the brain, then released into the bloodstream. Quantities naturally increase as the sun goes down and decrease during daytime hours and exposure to bright light, thus regulating the sleep-wake cycle (aka circadian rhythm).

When it’s produced within our bodies, it goes by the name endogenous melatonin; however, some also choose to supplement their natural levels as a way to effectively adjust and regulate their body’s internal clock if they have trouble sleeping. Unlike Benadryl, melatonin is non-habit-forming

Melatonin best for

Can you take Benadryl and melatonin

Melatonin is best for those suffering from circadian rhythm sleep disorders such as:

Jet lag

Officially known as “Rapid Time Zone Change Syndrome,” jet lag messes with your sleep times and wake times as you cross into new time zones, especially when traveling east.

Shift Work Disorder

Shift workers with inconsistent schedules have been found to get upwards of four fewer hours of sleep than the average person due to disrupted melatonin production. (13)

Delayed Sleep Phase Disorder (DSPS)

Night owls who fall asleep late but have a hard time getting up in the morning (common with teens and young adults).

Advanced Sleep Phase Disorder

Early birds whose body clock causes them to fall asleep and wake up on the early side (common with older adults).

Irregular Sleep-Wake Rhythm Disorder

When someone’s sleep patterns are flipped upside down due to one-too-many naps over a 24-hour period.

Can You Mix Melatonin and Benadryl?

Generally speaking, yes, you can mix melatonin and Benadryl, but you should be careful about certain side effects such as:

  • Dizziness
  • Drowsiness
  • Confusion
  • Difficulties with concentration

Older people may also experience poorer motor coordination as well as impairments in judgment and thinking.

It’s highly advisable not to use (or at least limit the use of) alcohol if you’re taking melatonin and Benadryl together. Also, don’t drive or operate heavy or dangerous machinery until you have more information on how Benadryl and melatonin affect you.

Whatever you consider doing, first talk to your doctor and tell them about your concerns and any questions you might have. Also, make sure to tell them about other medications you’re taking at the moment, even if it’s just herbs or supplements and vitamins.

Melatonin has more possible interactions than Benadryl

As mentioned, both melatonin and Benadryl can cause drowsiness. So it’s best to avoid taking them with other medications that cause drowsiness, such as benzodiazepines, muscle relaxants, or opioid pain medications.

It’s also a good idea to avoid drinking alcohol along with melatonin or Benadryl. Alcohol can further disrupt your sleep cycle. And when it’s combined with Benadryl, alcohol can make confusion and dizziness more likely.

Melatonin has a large number of other possible drug interactions, including:

  • Oral and injectable diabetes medications
  • High blood pressure medications
  • Medications that lower immune system activity
  • Blood thinners
  • Anti-seizure medications

Caffeine and oral birth control pills can increase melatonin levels. So if these are part of your daily routine, you may need a lower melatonin dose.

Before taking melatonin or Benadryl, it’s a good idea to show your pharmacist or provider an updated medication list to help them identify any potential interactions.

Taking Melatonin And Benadryl Together

Although they work via different mechanisms, melatonin and Benadryl are not recommended to be taken together.

The use of both Melatonin and Benadryl can cause additive CNS depression and sedation.

Some studies also show that the combination can increase the risk of a next-day ‘hangover’ effect.

Lastly, both drugs have contradictory effects. Benadryl disrupts the sleep-wake cycle while melatonin promotes a return to a healthy sleep-wake cycle.

In general, Benadryl is best used intermittently to produce sedation for acute problems with insomnia.

Melatonin is best suited in those with low melatonin levels, or who are in a situation in which their sleep-wake cycle is disrupted (e.g. due to jet lag or in night shift workers).

There are certainly some situations where taking both Benadryl and melatonin may be necessary (say for example you regularly take melatonin but need to use Benadryl to stem an allergic reaction), but be done consistently to help you sleep better .

FAQs List

1.What are the side effects of melatonin?

Answer : A small percentage of melatonin using to  have been found to experience next-day drowsiness/grogginess, sleepiness, headaches, and dizziness; however, clinically significant adverse events,  there is no evidence of a risk for serious.  As a precautionary measure, it’s recommended that users not drive or use machinery for four to five hours after taking melatonin in the case of impairment.

Before beginning any new dietary supplement regime to target sleep problems, it’s best to consult your healthcare provider for medical advice.

2.What are the side effects of Benadryl?

Answer : Outside of sleepiness and sedative effects of Benadryl, common short-term side effects include dry mouth, dizziness, and headaches.

3.Can you take Benadryl and sleep aid together?

Answer :  It’s best to avoid diphenhydramine while you’re taking sleep medications. pharmacist can recommend a safer combination of your daily health care.

4.What happens if you take melatonin and don’t sleep?

Answer : Taking too much melatonin can actually cause rebound insomnia —either rendering the supplement ineffective or worse, exacerbating your already sleepless nights further. You only need tiny doses of melatonin to support your natural sleep cycle.

5.Is melatonin better than a sleep aid?

Answer : Melatonin does tend to have less risky potential side effects than certain prescription sleep aids, Grandner says that but he adds that “melatonin is not a good alternative to prescription sleep medications.

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